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Effect Of Marijuana Use On Outcomes In Patients Undergoing Reduction Mammaplasty: A Retrospective Cohort Study
Nicolas Greige, MD
1,
Sami Ferdousian, MS1, Isabel A. Snee, BS
1, Rachel N. Rohrich, BS
1, Ryan P. Lin, MD
1, Rajiv P. Parikh, MD
2, Samer Jabbour, MD
1, Laura K. Tom, MD
2, Stephen B. Baker, MD
1, Kenneth L. Fan, MD
1.
1MedStar Georgetown University Hospital, Department of Plastic and Reconstructive Surgery, Washington DC, DC, USA, 2MedStar Washington Hospital Center, Department of Plastic and Reconstructive Surgery, Washington DC, DC, USA.
PURPOSE: This study aims to evaluate the relationship between marijuana consumption and postoperative outcomes in patients undergoing reduction mammaplasty (RM).
METHODS: A multi-center retrospective chart review was conducted on patients who underwent RM between August 2019 and January 2024. Patients reporting current or recent marijuana use (within 4 weeks of surgery) were categorized as marijuana users.
RESULTS: Of 693 patients undergoing 1,341 RM procedures, 667 patients (1,284 RM) were included in the final analysis. Marijuana users accounted for 130 patients (19.5%) and 254 RM procedures (19.8%). Marijuana users were younger (median age: 28.7 years, IQR: 13.7 vs 39.1 years, IQR: 13.0; p < 0.001) and had lower Charlson Comorbidity Index scores (p < 0.001). The median follow-up was 2.6 months (IQR: 3.8). Marijuana use was associated with a higher risk of hematoma formation (3.2% vs 1.0%; p = 0.008) and delayed wound healing (12.6% vs 8.5%; p = 0.047). Univariate analysis showed increased odds of hematoma formation (OR: 3.3, p = 0.012), delayed healing (OR: 1.5, p = 0.048), and deep surgical site infection (OR: 4.1, p = 0.047) in marijuana users. Multivariate regression identified marijuana use as an independent predictor of hematoma formation (OR: 3.0, p = 0.024) and delayed healing (OR: 2.0, p = 0.007).
CONCLUSION: Marijuana use in the perioperative period was associated with an increased risk of hematoma formation and delayed wound healing in patients undergoing RM. These findings highlight the need for evidence-based guidelines on perioperative marijuana use.
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