American Association of Plastic Surgeons
AAPS Home AAPS Home Past & Future Meetings Past & Future Meetings

Back to 2022 Posters


Fibrin Sealants Do Not Reduce The Rate Of Seroma Formation In Post-mastectomy Breast Reconstruction: A Systematic Review And Meta-analysis
Karen E M Massada, MD1, Meagan Wu, MA2, Theresa K. Webster, BS3, Juliet Panichella, BS3, Michael C. Coronado, BS3, Lindsay Talemal, BS3, Nicholas Elmer, BS2, Sthefano Araya, MD1, Sthefano Araya, MD1, Rohan Brebion, MD3, Pablo A. Baltodano, MD1, Sameer A. Patel, MD1.
1Fox Chase Cancer Center/ Temple University Division of Plastic and Reconstructive Surgery, Philadelphia, PA, USA, 2Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA, 3Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.

PURPOSE: Breast reconstruction using Deep Inferior Epigastric Perforator (DIEP) and Latissimus dorsi (LD) flaps following mastectomy are associated with seroma formation. We performed an updated systematic review and meta-analysis on the effects of fibrin sealant on donor site complications following DIEP and LD flap breast reconstruction.
METHODS: A comprehensive literature search was conducted in March 2021, using PubMed, OVID, and Cochrane. Articles analyzing the efficacy of fibrin glue in reducing donor site morbidity in DIEP and LD breast reconstruction were included. The outcomes assessed were seroma rate formation and duration of drainage.
RESULTS: 17,265 articles were screened, and 9 articles were selected for analysis, which comprised 632 surgical sites in 611 patients. When comparing fibrin glue and quilting to quilting alone, there was no significant difference in seroma formation (Pooled Risk Ratio (RR) 0.51). Similarly comparing fibrin glue alone to no fibrin glue, there was no significant difference in the rate of seroma formation (Pooled RR 1.03). There also was no significant difference in the duration of drainage in those who received fibrin glue versus those who did not (Pooled RR -0.85) and in those who received fibrin glue and quilting versus quilting alone (Pooled RR -2.13).
CONCLUSION: The existing literature supports that using fibrin glue is not associated with a decrease in seroma rate formation or drainage duration in DIEP and LD flaps.



Back to 2022 Posters