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The Long-term Efficacy Of Bont-a For Full Facial Rejuvenation In 400 Patients
Mauro Barone, Medicine, Plastic surgery1, Roberta D'Emilio, Medicine and surgery
2, Maria Grazia Caputo, Medicine and surgery
2, Giuseppe Rosati, Medicine and surgery
2, Paolo Persichetti, Medicine, Plastic surgery
1.
1Campus BioMedico di Roma, Roma, Italy,
2freelance, Roma, Italy.
PURPOSE: This study aims to demonstrate the long-term efficacy of BoNT-A and the muscular rebalancing that occurs with repeated treatments, despite its reversible effects.
METHODS:This single-center study enrolled 400 patients (380 women and 20 men, aged 35 to 85) from 2018 to 2024 Participants received full face and neck BoNT-A injections, repeating this treatment at least 3 or 4 times every six months, with dosages ranging from 120 to 160 units per session at specific standardized sites. Patient perspective was assessed postoperatively using the validated 5-point Merz scale, while pre- and post-treatment outcomes were evaluated through standardized photo and video documentation, by two independent surgeons using a 5-point VAS scale. Patients who had other aesthetic procedures during the observation period, had follow-ups shorter than two years, or contraindications (e.g., allergies to the toxin, neuromuscular diseases, pregnancy) were excluded.
RESULTS: Both the Merz scale and VAS evaluations indicated significant post-treatment improvement after the first session (p < 0.01). Notably, the improvement appeared to be maintained when comparing initial post-treatment assessments with those taken after three or four treatments (p < 0.001), supporting the hypothesis that results persist beyond the functional duration of BoNT-A after repeated sessions.
CONCLUSION: This study confirms the efficacy of BoNT-A for full face rejuvenating, suggesting that repeated treatments contribute to long-term stabilization of results. Additionally, BoNT-A not only offers temporary benefits but also induces muscular plasticity, which may be advantageous in supporting future surgical interventions, like facelifts, for maintaining results over time.
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